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目前的洞察力和研究差距补充剂的代谢健康:一个范围审查

Linda Morales-Juárez¹, Astrid Domínguez-Uscanga², Janet A Gutiérrez-Uribe²

¹Tecnológico de Monterrey, Institute for Obesity Research, Monterrey, NL 64849, México.

Nutrition reviews

|February 28, 2026

概括

补充剂通过减少炎症和胰岛素抵抗来改善代谢健康,特别是在患有糖尿病的成年人中. 最佳的剂量需要仔细考虑个体的状态,因为缺乏或过量可能会造成潜在的危害.

科学领域:

营养生物化学营养生物化学
代谢健康代谢健康
炎症和氧化压力炎症和氧化压力

背景情况:

对于新陈代谢健康,抗氧化防御和炎症调节至关重要.
了解的生理作用和病理相关性对于治疗补充策略至关重要.
目前的知识差距阻碍了制定安全有效的剂量指南.

研究的目的:

系统地绘制和合成关于补充对成年人炎症,氧化应激和葡萄糖脂质代谢的影响的证据.
确定与补充和代谢健康相关的知识差距.
为制定基于证据的剂量指南提供信息.

主要方法:

根据PRISMA-ScR指南进行了范围审查.
搜索主要的电子数据库进行临床试验,评估补充剂对成年人群中代谢疾病标志物的影响.
包括评估炎症,氧化应激和葡萄糖脂质代谢的研究.

主要成果:

在12周或更长时间的研究中,补充改善了代谢标志物,特别是减少了胰岛素抵抗 (HOMA-IR降低高达26%) 和炎症 (hs-CRP降低高达62.4%).
益处在患有糖尿病和胰岛素抵抗症的成年人中最为明显.
在多囊性卵巢综合征 (PCOS) 和绝经后妇女中,影响是模糊的,一些研究显示中性或不良影响.

结论:

补充剂可以提高胰岛素敏感性,降低hs-CRP,并增强抗氧化防御,特别是在患有糖尿病或胰岛素抵抗的成年人中.
的治疗窗口很窄;剂量必须根据基线状态来指导,以避免缺乏或过量.
需要进一步的长期,经过良好控制的试验,以确定最佳的疗法,并确定从补充中受益最多的特定人群.

关键词:

这是一种炎症炎症炎症炎症.代谢障碍代谢障碍代谢障碍肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖范围审查审查的范围审查.是一种.补充补充补充补充补充

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