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Updated: Mar 2, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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瘤学中的DNA甲基转移酶抑制剂:临床进展,局限性和未来方向

David C Michael1, Parinaz Mehdipour1

  • 1Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Epigenomics
|February 28, 2026
PubMed
概括

表观遗传疗法,包括DNA甲基转移酶抑制剂 (DNMTis),为癌症治疗提供了新的途径. 将DNMTis与其他药物结合使用,有望克服耐药性并改善结果,特别是在固体瘤中.

关键词:
DNA甲基转移酶抑制剂 (DNMTis) 的使用阿扎西蒂丁 (AZA) 是一种癌症治疗 治疗 治疗 癌症临床应用 临床应用组合疗法治疗组合治疗.迪西他 (DAC) 的使用表观遗传疗法是一种表观遗传疗法.

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