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在常规临床实践中,RISPERIDONE和PALIPERIDONE诱导的高血糖性:阿联的人口和药理学决定因素
Dina Aly El-Gabry1,2, Hind Mohd Ahmed3, Gabriel Andrade4
1Department of Psychiatry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
International clinical psychopharmacology
|February 28, 2026
概括
在阿联的精神分裂症患者中,抗精神病药物诱导的超分泌性血症很常见,特别是在口服帕利皮里的年轻女性中. 这凸显了该地区监测和量身定制的处方指南的必要性.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 抗精神病药物诱导的高益生菌性血症是多巴胺D2对手的常见不良影响.
- 在阿拉伯人口,特别是阿联人口中,有关高血性乳清血的证据有限.
- 里斯佩里和帕利佩里是常见的抗精神病药物,与这种副作用有关.
研究的目的:
- 在一个大型的阿拉伯联合长国 (UAE) 队列中调查抗精神病药物诱导的高血糖血症的患病率和预测因素.
- 为了确定与精神分裂症患者的高血清素水平相关的人口和药理学因素.
- 评估性副作用的发生情况及其不足的认可.
主要方法:
- 从2017年到2023年使用电子医疗记录进行了回顾性横截面研究.
- 纳入标准:被诊断为精神分裂症的成年人 (≥18岁) 接受了RISPERIDONE或PALIPERIDONE治疗,持续时间≥6周.
- 评估了血清前素水平,并分析了人口统计,药物和副作用的数据.
主要成果:
- 在835名患者中,61.9%的患者患有过高乳糖血症,平均乳糖水平为1126mIU/l.
- 口服帕利皮里组呈现出最高的平均益生素水平 (1369 mIU/l).
- 预测因素包括年龄较小,女性性别,非阿联国籍,帕利佩里使用和阿里皮普拉联合治疗. 在9.2%的病例中报告了性方面的副作用.
结论:
- 在这个阿联队列中,抗精神病药物诱导的超分泌性血症非常普遍,特别是在年轻的女性和服用口服帕利皮里的人群中.
- 与性相关的副作用的认识显著不足.
- 常规的内分泌监测,明智的处方以减少多药,以及特定区域的临床指南对于阿联和海湾地区至关重要.
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