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脂蛋白 (a) 在家族性高胆固醇血症中

Ali K Jaafar¹, Steeve Bourane², Gilles C Lambert²

¹EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.

Current opinion in lipidology

|February 28, 2026

概括

家庭高胆固醇血清症 (FH) 患者通常具有高脂蛋白[Lp (a) ],这是一个关键的心血管风险因素. 目前针对LDL胆固醇的治疗方法不能完全解决Lp(a) 风险,需要新的治疗方法.

科学领域:

心血管医学心血管医学
脂质代谢脂质代谢是什么
遗传学遗传学是一个

背景情况:

家庭性高胆固醇血症 (FH) 的特征是低密度脂蛋白 (LDL) 胆固醇的升高.
升高的脂蛋白 (Lp) 是心血管疾病 (CVD) 的重要,独立的危险因素.
高LDL胆固醇和高Lp (a) 的脂质概况对心血管健康尤其有害.

研究的目的:

审查2026年1月之前发表的关于Lp (a) 代谢的文献.
检查在FH患者中Lp(a) 和心血管疾病风险之间的关联.
了解Lp (a) 在FH脂质配置文件的背景下所起的作用.

主要方法:

系统的文献审查.
对Lp (a) 代谢和清除研究的分析.
评估临床证据对心血管疾病风险在FH与升高的Lp.

主要成果:

在FH队列中,Lp (a) 持续升高,部分原因是诊断标准.
LDL受体在Lp (a) 肝脏吸收中的作用不如以前想象的那么重要.
药理性降低LDL胆固醇并不能减轻FH中Lp (a) 升高所带来的特定心脏病风险.

结论:

建议在FH患者中进行系统的Lp (a) 测量.
高剂量的他类药物和PCSK9抑制剂对于在FH中实现LDL-C目标至关重要.
新兴的Lp(a) 降低疗法对治疗Lp(a) 升高的FH患者有前途.

关键词:

家庭性高胆固醇血症是什么?脂蛋白 (a) 是一种蛋白质低密度脂蛋白受体的受体是一种低密度脂蛋白受体.蛋白转化酶亚提利辛/凯类型9抑制剂

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