卵巢癌后患乳腺癌的风险在BRCA1或BRCA2中具有致病性/可能致病性变体的妇女中
Adriana I Apostol1,2, Jacek Gronwald3, Cezary Cybulski3
1Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
与没有卵巢癌的人相比,被诊断患有卵巢癌的BRCA携带者患乳腺癌的风险明显较低. 不建议进行常规的降低风险的乳房切除术,但对于长期幸存者来说,可以考虑监视.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 癌症流行病学 癌症流行病学
背景情况:
- 携带BRCA的携带者对乳腺癌和卵巢癌的风险都有所增加.
- 关于BRCA携带者在卵巢癌后诊断的风险降低乳房切除术的决定需要进一步进行风险评估.
研究的目的:
- 在卵巢癌诊断后,评估BRCA携带者的乳腺癌发病率.
- 为了比较 BRCA 携带卵巢癌的乳腺癌风险与没有卵巢癌的卵巢癌.
主要方法:
- 纳入标准:具有卵巢癌的BRCA1/BRCA2致病变体携带者,没有癌症史,没有降低风险的乳腺切除术.
- 从卵巢癌诊断发生的乳腺癌的随访日期.
- 与年龄相匹配的没有卵巢癌的BRCA携带者进行比较;计算5,10和15年后的累积风险.
主要成果:
- 分析了960名患有卵巢癌的BRCA携带者;4.3%的患者在平均随访4.9年后患有乳腺癌.
- 卵巢癌后的5,10年和15年的累积乳腺癌风险分别为4.4%,8.9%和11.5%.
- 患有卵巢癌的BRCA携带者与没有卵巢癌的携带者相比,乳腺癌风险明显较低 (HR=0.18).
结论:
- 被诊断为卵巢癌的BRCA携带者随后患乳腺癌的风险相对较低.
- 常规降低风险的乳房切除不建议,但可能会考虑长期幸存者.
- 磁力共振成像监测和乳房造影是监测乳腺癌风险的可行的替代方案.
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