面部移植后与神经适应相关的感觉回归:一个多中心队列研究
Lioba Huelsboemer1, Pauliina Homsy2, Juan P Barret3
1Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, 330 Cedar St, 06519 New Haven, CT, United States of America; Department of Plastic Reconstructive, Aesthetic and Hand Surgery, Burn Unit, Sana Hospital Offenbach, Goethe University Frankfurt, Starkenburgring 66, 63069 Offenbach am Main, Germany.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
|February 28, 2026
概括
全面移植显示有希望的感官恢复,广泛的神经合可能会改善结果. 神经移植和受伤类型等因素也会影响移植后的长期面部感觉.
科学领域:
- 重建性手术是一种重建性手术.
- 神经外科 神经外科
- 移植免疫学 移植免疫学
背景情况:
- 对面部移植后的功能结果来说,感官恢复至关重要.
- 评估感官恢复和神经合是改善患者结果的必要条件.
- 使用多中心方法来评估面部移植接受者的感觉恢复.
研究的目的:
- 评估面部移植患者的感觉恢复和神经合.
- 为了比较全脸和部分脸部移植之间的感觉结果.
- 识别影响面部移植后长期感官功能的因素.
主要方法:
- 分析了来自五个中心的18例面部移植 (11例完全,7例部分) 的数据.
- 记录了手术神经接收细节和三角神经分支的参与.
- 通过使用温斯坦增强感官测试 (WEST) 和在早期和晚期的时间点进行热/冷歧视来评估感官结果.
主要成果:
- 所有移植都实现了压力感觉;大多数实现了热/冷区分.
- 全面移植患者在晚期随访 (p=0.051) 显示,与部分移植患者 (74%) 相比,全面移植患者的压力感觉有所改善 (90%).
- 在全面移植 (85%) 和部分移植 (64%) 中,热/冷区分较高,患者间差异很大.
结论:
- 在全面移植中,广泛的神经合可能与更好的感官恢复有关.
- 神经移植技术和患者特异性因素会影响长期的感官功能.
- 为了优化结果,需要对神经再生进行标准化协议和研究.
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