标题:在通过离心技术进行低体积血交换的肝病患者中,症状性低血症不常见
Stephan Benny1, K C Gayathiri2, Vijay Alexander1
1Department of Hepatology, Christian Medical College, Vellore, India.
概括
在接受低体积血交换 (PLEX-LV) 和补充的肝病患者中,低血是不常见的. 然而,患有急性肝损伤/衰竭 (ALI/ALF) 的患者面临更高的风险,需要仔细监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 关键护理医学 关键护理医学
背景情况:
- 血交换中的酸盐抗凝剂 (PLEX) 可能导致低血症,特别是在肝脏疾病中,由于酸盐代谢受损.
- 低容量PLEX (PLEX-LV) 用于肝衰竭综合征,但低血症风险需要调查.
研究的目的:
- 确定PLEX-LV.接受治疗的肝衰竭患者中低血症的发生率和预测因素.
- 在PLEX-LV期间评估协议化补充剂的安全性和有效性.
主要方法:
- 研究了一系列连续接受离心PLEX-LV (50%血体积) 的成年患者.
- 使用酸酸甲糖-A,每次服用20毫升10%的糖酸盐.
- 在PLEX前和后测量了血清校正的水平,低血症定义为<8.4 mg/dL.
主要成果:
- 在276名患者中 (924次),14.1%的人患有低血症 (5.8%的会议).
- 急性肝损伤/衰竭 (ALI/ALF) 患者的低血症显著高,特别是那些具有杀鼠剂毒性 (p<0.001) 的患者.
- ALI/ALF是缺血的唯一独立预测因子 (OR 6.85,p<0.001).
结论:
- 在接受PLEX-LV与补充治疗的肝病患者中,症状性低血症很少见.
- 建议对水平进行密切监测,特别是对于患有ALI/ALF的患者.
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