对于患有阻塞性睡眠呼吸障碍的儿童的积极策略:系统性审查和元分析
Pierre Cnockaert1, Julien Da Purificaçao2, William Poncin1
1Pole of Pulmonology, ENT and Dermatology (LUNS), Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium; Service de Pneumologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Sleep medicine
|February 28, 2026
概括
像肌功能疗法这样的积极策略不被支持作为儿科阻塞性睡眠呼吸障碍 (OSDB) 的一线治疗. 目前的证据表明,OSDB儿童的客观睡眠结果没有显著改善.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 呼吸系统医学 呼吸系统医学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 积极的策略,包括肌功能疗法 (MFT),越来越多地被认为用于管理儿科阻塞性睡眠呼吸障碍 (OSDB).
- 本元分析评估了这些积极策略对儿童客观睡眠结果的有效性.
研究的目的:
- 对积极策略对儿科阻塞性睡眠呼吸障碍 (OSDB) 的客观睡眠结果的影响进行元分析.
- 主要结局: 呼吸暂停-呼吸暂停指数 (AHI). 二次结果:平均值和最低值 SpO2.2.
主要方法:
- 以PRISMA为指导的系统审查和元分析.
- 搜索了PubMed,Scopus,Embase和PEDro数据库,截至2026年1月.
- 包括研究检查积极策略作为儿童OSDB的孤立干预;使用RoB 2.0和ROBINS-I V2.2评估偏差风险.
主要成果:
- 包括8篇文章 (7个MFT,1个练习),其中大多数具有严重的偏见风险.
- 在随机对照试验 (RCT) 中,没有观察到MFT在AHI或平均SpO2的统计学意义上的变化.
- 非随机对照试验 (nRCTs) 也没有显示MFT的AHI或SpO2底有显著变化.
结论:
- 目前的证据不支持使用孤立的,积极的策略作为儿科OSDB的第一线治疗.
- 需要进一步进行高质量的研究,以澄清积极策略在OSDB管理中的作用.
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