某些乳糖脂肪酸单的酶合成,乳化特性和结构-活性关系
Mengfei Xie1, Haocong Wang1, Yangjiao Ye1
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.
研究人员开发了新的乳糖单作为有效的乳化剂. 这些糖脂肪酸化合物对生物活性输送系统有前途,因为它们的调节性质和在消化过程中受控释放.
科学领域:
- 食品化学 食品化学
- 表面活性剂科学 表面活性剂科学
- 生物材料是一种生物材料.
背景情况:
- 来自糖和脂肪酸的 Ester 可以作为多功能表面活性剂.
- 乳糖具有已知的益生菌性质,这表明其衍生物在功能应用中的潜力.
研究的目的:
- 为了合成和评估乳糖单与不同的乙侧链长度 (C8-C18) 作为乳化剂.
- 为了确定这些新型表面活性剂的结构-活性关系.
- 评估它们在皮克林乳液和模拟消化过程中的性能.
主要方法:
- 乳糖单的合成与C8到C18的乙侧链.
- 乳化剂性能评估,包括水性-脂性平衡 (HLB) 值.
- 确定关键菌度 (CMC) 和界面活动.
- 皮克林乳液的形成和稳定性评估.
- 实验室模拟消化研究,以评估滴滴的完整性和自由脂肪酸的释放.
主要成果:
- 乳糖单的HLB值从11到17不等.
- 增加疏水性侧链长度 (C8-C16) 降低了CMC,增强了界面活性和乳化能力.
- C18侧链 Ester 形成稳定的皮克林乳液,保质期至少为 15 天.
- 乳液在口腔和胃阶段保持完整性,但在肠道条件下释放60%-90%的自由脂肪酸.
结论:
- 乳糖单的结构与活性之间建立了明确的关系,侧链长度与表面活性剂特性相关.
- 这些化合物显示出作为食品和制药应用中的功能成分的巨大潜力.
- 乳糖单适合开发具有控制释放特性的先进生物活性输送系统.
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