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软物质工程的pH响应水凝用于封装,保护和控制益生菌 (Lacticaseibacillus paracasei YWC-01) 的肠道释放

Xiaoyu Cao¹, Sisheng Li², Qianqian Xu¹

¹School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.

|February 28, 2026

概括

豆蛋白分离剂和点水凝微囊有效地将益生菌Lacticaseibacillus paracasei YWC-01输送到肠道,显著改善了其生存和生物活性.

科学领域:

生物材料科学生物材料科学
食品科学食品科学食品科学
微生物学微生物学

背景情况:

益生菌需要有效的输送系统才能在胃肠道中存活并发挥有益作用.
有针对性的输送可以提高益生菌的有效性和潜在的健康益处,例如肠道微生物群的调节.

研究的目的:

开发适应pH的水凝微囊,用于向肠道输送Lacticaseibacillus paracasei YWC-01.1.
评估封装益生菌的封装效率,稳定性和生物活性.

主要方法:

使用豆蛋白分离物 (PPI) 和低甲基 (LMP) 通过乳液模板制造制造 pH 响应的水凝微囊.
在模拟消化条件下,微囊特性 (大小,封装效率) 和益生菌生存能力的表征.
代谢分析以评估封装对益生菌生物活性的影响.

主要成果:

优化的PPI-LMP微囊实现了Lacticaseibacillus paracasei YWC-01.1.的94.80%封装效率.
在体外消化后,封装的益生菌表现出明显增强的活力 (>9 log10 CFU/g) 与自由细胞相比.
代谢分析揭示了封装益生菌中保存的生物活性和上调的功能代谢物.

结论:

豆蛋白分离物和低甲基胺水凝微囊提供了一个有效的平台,用于针对性地向肠道输送益生菌.
这种输送系统显著提高了益生菌的胃肠道存活率,并保持了它们的功能生物活性.
开发的微囊有可能通过增强益生菌疗效来改善肠道健康.

关键词:

生物可用性生物可用性有控制释放的释放.水凝珠子的珠子在体外消化过程中消化.提供益生菌的传递.

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