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患有多发性硬化症的妇女剖腹产后感染的风险:基于人口的队列研究
Mette Louise Andersen1, Line Riis Jølving2, Maria Iachina2
1Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, Denmark; Department of Gynecology and Obstetrics, University Hospital of Southern Jutland, Esbjerg, Denmark.
与阴道分娩相比,通过剖腹产分娩的患有多发性硬化症 (MS) 的妇女面临更高的产后感染风险. 这种增加的感染风险可能会使MS症状恶化或引发复发.
科学领域:
- 产科和妇科 产科和妇科
- 神经学 神经学
- 传染病流行病学 传染病流行病学
背景情况:
- 剖腹产率正在上升,特别是在患有多发性硬化症 (MS) 的女性中.
- 在MS的妇女中,CS和阴道分娩后产后感染的母亲的比较风险仍然不清楚.
研究的目的:
- 调查分娩方式 (CS与阴道分娩) 与患有多发性硬化症 (MS) 的妇女产后感染的风险之间的关联.
主要方法:
- 利用丹麦国家卫生登记册对MS妇女活产的队列研究 (1995-2023年).
- 使用后勤回归模型,调整混因素 (年龄,BMI,并发症),以根据分娩方式估计感染风险.
主要成果:
- 在患有多发性硬化症的妇女中分析了872例CS分娩和2542例阴道分娩的队列.
- 接受CS治疗的MS患者在42天内患产后感染的风险增加了54% (aOR 1.54,95% CI 1.18-2.01).
- 轻度至中度感染 (抗生素处方) 的aOR为1.60 (95%CI为1.24-2.08),而严重感染 (在医院诊断) 的aOR为1.55 (95%CI为0.82-2.94).
结论:
- 与阴道分娩相比,通过剖腹产分娩的患有多发性硬化症 (MS) 的女性患产后感染的风险明显更高.
- 意识到这种感染风险增加至关重要,因为感染可能会加剧神经系统症状或在MS患者中引发新的复发.
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