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在小鼠中,Enterococcus faecalis通过类似M1的巨细胞两极分化促进了正牙牙移动

Fei Yu¹, Ting Jiang², Wenxin Lu³

¹State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Archives of oral biology

|February 28, 2026

概括

在小鼠中,Enterococcus faecalis (E. faecalis) 的使用通过调节巨细胞两极分化和骨质活动,加速了正牙牙移动 (OTM). 这表明一种潜在的非侵入性策略来增强OTM.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
矯正牙科矯正牙科是一種矯正牙科.

背景情况:

益生菌疗法在影响骨重塑方面表现有前途.
ортодонтика牙运动 (OTM) 是一个复杂的生物过程,涉及骨重塑.
微生物可能在调节OTM方面发挥作用.

研究的目的:

研究特定微生物对加速正统牙移动 (OTM) 的影响.
在OTM小鼠模型中探索候选益生菌的骨免疫调节作用.

主要方法:

16S rRNA基因测序在OTM小鼠模型中确定了潜在的益生菌候选者.
主要小鼠牙周带细胞 (PDLCs) 用暴露于微生物的巨细胞的条件介质进行治疗.
进行了抗生素 (ABX) 的微生物群消耗,然后给予微生物.
通过OTM距离,微型CT和免疫组织化学分析了膜骨变化.

主要成果:

在OTM组中,Enterococcus faecalis (E. faecalis) 的数量增加.
E. faecalis促进了M1巨细胞的两极分化,并降低了PDLCs中的骨质性水平.
在接受抗生素治疗的小鼠中,E. faecalis的使用加速了OTM.

结论:

通过免疫调节,E. faecalis的使用会影响OTM.
这项研究为开发基于微生物的干预措施提供了基础,以加速OTM.
潜在的安全,非侵入性的策略,以提高正牙治疗的结果.

关键词:

骨改造骨改造骨改造骨改造菌 (Enterococcus faecalis) 是一种菌.免疫调节是一种免疫调节.巨细胞激活活动矯正牙科矯正牙科是一種矯正牙科.益生菌益生菌益生菌

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