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自由选择的嗅觉训练与药物治疗相结合的附加效应:对病毒后嗅觉功能障碍的回顾性分析

Hiroyuki Morishita¹, Masayoshi Kobayashi¹, Kohei Nishida¹

¹Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Auris, nasus, larynx

|February 28, 2026

概括

嗅觉训练 (OT) 与标准药物治疗相结合,可显著改善病毒后嗅觉功能障碍 (PVOD) 患者的嗅觉丧失. 这种组合治疗加快了恢复速度,并增加了PVOD的整体改善率.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经学神经学
临床医学临床医学

背景情况:

后病毒性嗅觉功能障碍 (PVOD) 是一种常见的疾病,其特点是呼吸道感染后失去嗅觉.
目前的药物疗法 (例如,tokishakuyakusan,硫酸,维生素B12) 在治疗PVOD方面表现出有限的疗效.
嗅觉训练 (OT) 已成为对神经感官嗅觉损失的有希望的干预措施.

研究的目的:

评估嗅觉训练 (OT) 与PVOD患者的常规药物治疗相结合时的附加治疗效果.
为了比较组合治疗与单独药物的疗效,改善嗅觉功能和恢复时间.

主要方法:

在2008年至2024年期间治疗的107名PVOD患者的回顾性分析.
单独使用药物组 (托基沙库亚库山,硫酸,甲基可巴胺) 与组合组 (药物+OT) 的比较.
排除COVID-19相关的嗅觉功能障碍;通过T&T嗅觉测量进行评估.

主要成果:

组合组在6个月后表现出明显更大的嗅觉功能的改善 (p=0.016).
在组合组 (90%) 与单独药物组 (69%) (p=0.010) 中观察到更高的最终改善率.
组合疗法导致平均恢复时间更短 (8个月与14个月,p=0.001),OT是改善的独立因素 (OR=4.96).

结论:

将传统药物治疗与嗅觉训练相结合,为PVOD患者的嗅觉恢复提供了额外的好处.
这种综合方法提高了改善率,缩短了恢复期.
自由选择的OT协议是PVOD管理的实用和有效的临床策略.

关键词:

气味剂的选择香料的选择嗅觉培训嗅觉培训嗅觉培训后病毒性嗅觉功能障碍后病毒性嗅觉障碍这是T&T的嗅觉测量.托基沙库亚库山 (Tokishakuyakusan) 是一个非常古老的城市.

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