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Updated: Mar 2, 2026

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

Published on: October 18, 2022

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资源竞争塑造了CRISPR介导的基因激活.

Krishna Manoj Aravind1, Domitilla Del Vecchio2

  • 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell systems
|February 28, 2026
PubMed
概括

由于引导RNA干扰和意想不到的抑制,CRISPR基因激活 (CRISPRa) 系统面临着可扩展性的挑战. 一个新的模型有助于优化多基因CRISPRa,以获得更好的动态范围和设计.

关键词:
通过CRISPR介导的基因激活克里斯普拉是一个.上下文依赖性 - - 上下文依赖性基因调节 基因调节 基因调节这是模块化的模块化.反应网络模型的反应网络模型.资源的竞争 资源的竞争合成生物学 合成生物学系统生物学 系统生物学

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