通过皮肤进行的耳道迷走神经刺激的胰岛调节效应治疗功能性消化不良症
1Guang'anmen hospital, China Academy of Chinese Medical Sciences, Beijing, China; Institute of Basic Research Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Journal of affective disorders
|February 28, 2026
概括
通过皮肤耳道神经刺激 (taVNS) 通过改变大脑连接来改善功能性消化不良 (FD) 症状. 在FD患者中,这种治疗使前侧岛膜 (AI) 和后侧前额皮层 (DLPFC) 的功能连接 (FC) 正常化.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 功能性消化不良 (FD) 是一种常见的胃肠道疾病.
- 之前的研究表明,通过皮肤进行耳耳神经刺激 (taVNS) 可以缓解FD症状.
- 在FD中TaVNS效应背后的精确大脑机制在很大程度上是未知的.
研究的目的:
- 为了研究taVNS在患有FD的患者中的大脑调制效应.
- 用静止状态功能磁共振成像 (rs-fMRI) 来探索与taVNS治疗FD相关的功能连接 (FC) 的变化.
主要方法:
- 招募了21名FD患者和30名健康对照 (HC).
- 在8周的taVNS治疗之前和之后,FD患者接受了rs-fMRI扫描.
- 分析了基于voxel的功能连接 (FC) 和相关性,以确定taVNS诱导的大脑变化.
主要成果:
- 在taVNS治疗后,FD患者报告了显著的症状改善.
- 在FD患者中,左背前胰岛 (dAI) 和左背侧前额皮层 (DLPFC) 之间的基线FC在FD患者中高于HC患者.
- taVNS治疗导致前面岛屿 (AI) 亚区域和DLPFC,杏仁体和视觉网络区域等区域之间广泛减少FC.
结论:
- FD患者在AI和DLPFC之间表现出异常的FC.
- taVNS有效地减轻了FD的症状.
- 在FD中taVNS的治疗效果可能包括在AI,中央执行网络 (CEN),边缘系统和视觉网络 (VN) 之间调节FC.
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