口腔腔癌的预后中的性别差异
Júlia Gayà1, Xavier Moix2, Cristina Valero1
1Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, C/ Mas Casanovas 90, 08041 Barcelona, Spain.
Acta otorrinolaringologica espanola
|February 28, 2026
概括
患有口腔状细胞癌的女性的癌症特异性生存率明显低于男性,即使有毒物质暴露率较低. 这凸显了在治疗口腔癌时需要针对性别进行预后考虑的必要性.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 公共卫生 公共卫生
背景情况:
- 口腔状细胞癌 (OCSCC) 是一个重要的全球健康问题.
- 在OCSCC中生存结果可能受到各种因素的影响,包括患者人口统计和暴露于有毒物质.
- 了解OCSCC预后的性别差异对于定制治疗策略至关重要.
研究的目的:
- 为了研究性别对OCSCC患者的生存结果的影响.
- 在高暴露区域分析影响癌症特异性生存率 (CSS) 和整体生存率 (OS) 的预后因素.
- 确定女性性别是否是OCSCC结果的独立预后因素.
主要方法:
- 在1985年至2020年期间诊断和治疗的857名OCSCC患者的回顾性分析.
- 根据性别评估的生存结果 (CSS和OS).
- 多变量分析包括年龄,有毒物质暴露,瘤位置和治疗类型.
主要成果:
- 五年CSS在女性中 (52.3%) 与男性 (67.0%) 相比显著较低.
- 女性性别是CSS的独立负预后因素 (HR 1.55).
- 较差的CSS与年龄较大,舌头/口腔粘膜瘤和晚期相关. 女性有更多的舌头/牙瘤和息治疗.
结论:
- 患有OCSCC的女性患者表现出更差的癌症特异性存活率,尽管有毒物质暴露率较低.
- 潜在的生物学或荷尔蒙差异可能导致女性的治疗结果较差.
- 性别特定的预后因素应纳入OCSCC管理.
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