在体外受精后的卵巢反应和活产的种族/民族差异
Iris T Lee1, Nathanael Koelper1, Monica Mainigi1
1Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA.
Fertility and sterility
|February 28, 2026
概括
与白人女性相比,接受体外受精 (IVF) 的黑人女性表现出更高的卵巢敏感性,但活产率较低. 这些差异表明,卵巢反应以外的因素影响了试管婴儿的成功.
科学领域:
- 生殖内分泌学和不孕不育问题
- 临床产科和妇科 临床产科和妇科
- 健康差异研究 研究健康差异研究
背景情况:
- 在接受体外受精 (IVF) 的种族/民族群体中,卵巢对淋巴激素刺激的反应有所不同.
- 了解这些变异对于优化试管婴儿方案和解决治疗结果的潜在差异至关重要.
研究的目的:
- 评估在IVF刺激期间卵巢反应的种族/种族差异.
- 为了比较不同种族/种族群体的卵巢反应率和活产率之间的关联.
主要方法:
- 来自辅助生殖技术学会诊所结果报告系统的246,132次试管婴儿周期 (2017-2019) 的回顾性队列研究.
- 卵巢敏感度指数 (OSI) 计算为 (检索卵细胞 / 淋巴激素剂量 × 1000),根据年龄,BMI,前周期,AMH和不孕症诊断进行调整.
- 分析了累积活产率,按种族/种族分层,并对混因素进行调整.
主要成果:
- 与白人和亚裔参与者相比,黑人参与者表现出更高的OSI (p<0.001).
- 尽管OSI较高,但与白人参与者相比 (60.8%) (p<0.001),黑人参与者的累积活产率 (45.5%) 显著较低 (p<0.001).
- 较高的OSI始终与所有组累积活产概率的增加有关,种族/种族没有显著的相互作用 (p=0.33).
结论:
- 虽然较高的卵巢反应率与IVF活产几率的增加有关,但种族/民族差异仍然存在.
- 黑人参与者表现出较高的卵巢反应能力,但较低的活产率,表明除了刺激反应之外的因素有助于结果差异.
- 需要进一步的研究来确定和解决这些不平等的IVF成功的根本原因.
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