诺福维尔阿拉芬胺防止HBV在抗癌/免疫抑制中重新激活:为期24个月的多中心前性研究
Goki Suda1, Masatsugu Ohara1, Masaru Baba2
1Departments of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
The Journal of infection
|February 28, 2026
概括
在高风险患者中,天诺福维尔阿拉芬胺 (TAF) 在24个月内有效防止乙型肝炎病毒 (HBV) 再激活和相关的肝炎. 没有发生严重的不良事件或治疗中断,证明TAF.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 乙型肝炎病毒 (HBV) 再激活对接受免疫抑制或抗瘤疗法的患者构成重大风险.
- 诺福维尔阿拉芬胺 (TAF) 是一种核酸模拟剂,在HBV预防中具有有利的安全性.
- 之前的研究评估了TAF对HBV再激活的预防,长达12个月.
研究的目的:
- 报告一项前性研究的最终24个月随访结果,评估特诺福维尔阿拉芬胺 (TAF) 预防HBV复激活.
- 评估TAF在HBV携带者和接受免疫抑制治疗的HBV感染已消失的患者的长期有效性和安全性.
主要方法:
- 一项多中心前性研究招募了191名患有HBV重新激活风险的患者.
- 患者在免疫抑制/抗原药治疗之前或期间接受了预防性TAF.
- 在12个月和24个月后评估了有效性,主要终点是HBV活性和与活性相关的肝炎.
主要成果:
- 127名患者完成了24个月的随访.
- 在TAF完成24个月的患者中,没有发生HBV再激活或与再激活相关的肝炎.
- 一名患者在TAF discontinuation后出现病毒性复发,但在重新开始时实现了病毒抑制;没有患者切换到恩特卡维尔被重新激活.
结论:
- 诺福维尔阿拉芬胺 (TAF) 在24个月内在预防HBV复激活和与复激活有关的肝炎方面表现出持续的有效性.
- TAF是HBV携带者和接受免疫抑制治疗的HBV感染已消失的患者的安全和有效的预防方案.
- 没有报告因TAF相关不良事件而导致治疗中断.
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