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在单次和多次食物口服免疫疗法期间发生的eosinophilic食道炎

Timothy M Buckey¹, Jess Frangiosa², Luca Diem²

¹Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Section of Allergy and Immunology, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

|February 28, 2026

概括

针对食物过敏的口服免疫疗法 (OIT) 可以导致异氨酸性食道炎 (EoE). 这项研究发现,在OIT的1200名儿童中,EoE诊断率为0.7%,这凸显了定期查的重要性.

科学领域:

过敏和免疫学过敏和免疫学
胃肠病学胃肠病学
儿科医学儿科医学

背景情况:

口服免疫疗法 (OIT) 越来越多地用于IgE介导的食物过敏.
性食道炎 (EoE) 是OIT的一种已知的不良影响.

研究的目的:

为了确定在接受OIT的儿童中新出现的乙酸性食道炎 (EoE) 诊断的发生率.
为了比较单一与多种食品OIT中的EoE发展.
在OIT期间识别与EoE相关的症状和食物.

主要方法:

从2018年到2024年5月接受OIT的1200名儿科患者的回顾性审查.
对疑似EoE症状的患者进行评估.

主要成果:

在1200名儿童中,有8名 (0.7%) 被诊断出患有EoE.
单一和多种食品OIT之间没有明显的EoE发病率差异.
花生和蛋OIT最常与暗示EoE的胃肠道症状有关.

结论:

在这个队列中,OIT期间新诊断的EoE率为0.7%,低于之前报告的.
在OIT之前和期间定期对EoE进行查与发病率降低有关.
在OIT期间持续的胃肠道症状可能表明EoE的风险较高.

关键词:

埃索诺菲尔性食道炎是什么?食物过敏食物过敏口服免疫疗法是一种口服免疫疗法.

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