处理诱导的结构改造通过肠道微生物群-SCFA-GPR41/43通路增强了Polygonatum cyrtonema Hua多糖的低血糖活性
Chuyao Deng1, Jiaxin Zheng1, Fei Xu2
1Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Sciences, South China Agricultural University, Guangzhou, China.
Food research international (Ottawa, Ont.)
|February 28, 2026
概括
经过加工的Polygonatum cyrtonema 华多糖体通过改善肠道健康和葡萄糖调节,显示出增强的抗糖尿病作用. 传统加工增强了多糖生物活性,用于功能性食品的开发.
科学领域:
- 药理学和自然产品化学化学
- 代谢障碍和内分泌学
- 微生物组和肠道健康
背景情况:
- 2型糖尿病 (T2DM) 带来了重大的健康和经济挑战,常规治疗造成了不良影响.
- 自然的多糖因其生物活性而被探索为管理T2DM的更安全的替代品.
- (P. cyrtonema) 是一种具有潜在治疗功能的传统草药.
研究的目的:
- 从原始 (RPCP) 和加工 (PPCP) P. cyrtonema Hua.中提取和描述多糖类.
- 在T2DM小鼠模型中评估低血糖效应并阐明RPCP和PPCP的机制.
- 研究传统加工在增强多糖生物活性方面的作用.
主要方法:
- 用酶辅助的热水从P.cyrtonema Hua.中提取多糖.
- 使用分子量,单糖化合物组成,FT-IR,甲基化和NMR进行结构性表征.
- 评估高脂肪饮食/链毒素诱导T2DM小鼠的低血糖效应和机制,包括肠道微生物群分析,SCFA生产和激素水平测量.
主要成果:
- 在T2DM小鼠中,RPCP和PPCP都显著降低了禁食血糖,提高了胰岛素敏感性,改善了脂质障碍.
- 多糖调节了肠道微生物群,增加了短链脂肪酸 (SCFA) 生产,提高了结肠GPR41/43的调节,并增强了GLP-1和PYY分泌.
- 与RPCP相比,PPCP表现出优越的抗糖尿病作用,这归因于其增强的分子异质性和富含银河的结构,表明加工效益.
结论:
- 传统的加工,如蒸,可以增强P. cyrtonema Hua多糖的生物活性.
- 抗糖尿病作用通过肠道微生物群-SCFA-宿主代谢轴进行介导,影响葡萄糖平衡.
- 果糖多糖,特别是加工形式,显示出作为功能性食品成分对血糖调节的承诺.
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