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Updated: Mar 2, 2026

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

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基于codon优化的基数编辑器可以在大西洋鱼中有效地进行基数替换

Jinhai Wang1, Jiaqi Wang2, Alexandra Florea2

  • 1The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK; College of Animal Science and Technology, Northwest A&F University, Yangling 712100, PR China.

Trends in biotechnology
|February 28, 2026
PubMed
概括

我们优化了大西洋鱼的基础编辑器 (BEs),使用鱼喜欢的编码子,提高基因编辑效率,减少非模型生物体的意外编辑. 这一进步扩大了鱼生物技术的工具箱.

关键词:
大西洋鱼是大西洋鱼.这就是Cas9的情况.水产养殖的水产养殖基础编辑 基础编辑疾病模型的疾病模型.

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