在高风险和研究不足的群体中,HPV疫苗的免疫性:女性性工作者

在高风险和研究不足的群体中,HPV疫苗的免疫性:女性性工作者

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Trang Van Nguyen¹, Le Anh Tuan¹, Chu Thi Ngoc Mai¹

¹National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.

The Journal of infectious diseases

|March 1, 2026

概括

女性性工作者 (FSW) 对四价HPV疫苗 (4vHPV) 显示出强烈的免疫反应,所有参与者在7个月后都会产生保护性抗体. 这表明4vHPV疫苗接种是这个高风险群体的可行策略.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

女性性工作者 (FSW) 因多个性伴侣而面临人类乳头瘤病毒 (HPV) 感染的风险增加.
在FSW疫苗接种HPV疫苗的免疫性尚不清楚,特别是关于潜在的先前存在的HPV暴露.

研究的目的:

评估四价HPV疫苗 (4vHPV) 在越南FSW中的免疫性.
评估与基线HPVDNA状态相关的HPV疫苗中和抗体 (NAb) 反应.

主要方法:

一项试点研究涉及越南63名年龄在18-26岁的FSW.
参与者接受了4vHPV疫苗的三剂计划.
收集了宫拭片和血液样本,以评估HPV DNA和NAb对HPV16,18,52和58的反应.

主要成果:

高风险HPVDNA的基线患病率为28.6%,其中9.5%的检测结果为HPV16/18阳性.
在第一剂后,对HPV16和HPV18的血清阳性分别达到90%和55%.
到第7个月,所有参与者都获得了HPV16和HPV18的血清阳性,在HPV-DNA阴性个体中观察到更高的NAb反应.

结论:

三剂4vHPV疫苗接种方案在FSW中引起了针对HPV16和HPV18的强大的中和抗体反应.
需要进一步的研究来证实HPV疫苗在这个人群中的有效性.

关键词:

感染HPV病毒的感染.这种疫苗是HPV疫苗.越南越南越南越南女性工作者是什么意思免疫性免疫性免疫性

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