败血症 这是一种败血症
Mervyn Singer1, Derek C Angus2, Djillali Annane3
1Bloomsbury Intensive Care Medicine Institute, Centre for Respiratory Medicine, University College London, London, UK.
Lancet (London, England)
|March 1, 2026
概括
败血症是感染导致的危及生命的器官功能障碍,涉及复杂的免疫反应,受许多因素的影响. 了解败血症变异性是个性化治疗和改善全球结果的关键.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 败血症是一种严重的医疗紧急情况,其特点是宿主对感染的反应失调,导致器官功能障碍.
- 它涉及复杂的免疫系统激活和抑制,影响多个身体系统.
- 影响败血症风险的因素包括病原体特征,感染地点,宿主遗传,并发病,年龄和环境影响.
研究的目的:
- 提供全面的毒综述,包括其流行病学,病理生理学和管理.
- 突出毒症呈现和进展的复杂性和变异性.
- 讨论毒症研究和临床实践当前的挑战和未来的方向.
主要方法:
- 关于败血症流行病学和病理生理学的当前文献的综述.
- 分析导致宿主易感性和疾病进展的因素.
- 讨论不断发展的治疗策略和生物标志物开发.
主要成果:
- 败血症的发病因子是多因素的,涉及复杂的宿主-病原体相互作用和免疫失调.
- 由于毒症的生物特征和时间变异不同,需要个性化治疗方法.
- 尽管取得了进展,但败血症仍然是全球死亡的主要原因,这强调了平等获得护理的必要性.
结论:
- 败血症是一种复杂的综合征,需要对其潜在生物学有多方面的理解.
- 以生物标志物为指导的个性化药物对于有效的败血症管理至关重要.
- 需要全球努力,以改善所有人群的败血症预防,早期检测和治疗.
相关概念视频
Asepsis
3.6K
The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
3.6K
Hand hygiene
6.3K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
6.3K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
6.0K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
6.0K
Pneumonia III: Complications and Assessment
1.0K
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.0K
Infection
13.1K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
13.1K
Urinary Tract Infection II: Pathophysiology
921
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
921


