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瘤形成的血小板:从分子机制到液体活检和治疗应用

Zhuqian Li¹, Jingze Liu¹, Man Yan²

¹School of Health Nursing, Zhenjiang College, Zhenjiang, Jiangsu, China.

International journal of pharmaceutics

|March 1, 2026

概括

瘤将血小板重新编程成由瘤形成的血小板 (TEPs),促进癌症的进展. TEP 具有作为液体活检工具的潜力,但临床使用仍然存在挑战.

科学领域:

在瘤学瘤学.
血液学血液学血液学
分子生物学分子生物学

背景情况:

血小板越来越多地被认为是超越血静的作用,积极参与瘤生物学.
瘤可以通过分子交换将循环血小板重新编程成瘤培养血小板 (TEP),从而改变它们的功能.

研究的目的:

审查瘤血小板形成的分子机制.
分析TEPs的前瘤功能.
评估TEP在癌症诊断和治疗方面的转化潜力.

主要方法:

对有关血小板重编程和TEP功能的现有文献的综述.
分析分子机制,包括细胞外囊泡转移和RNA处理.
评估TEPs作为液体活检和治疗点.

主要成果:

血小板重编程涉及分子载荷交换,RNA处理和受体重塑.
TEPs促进血管新生,抗氧化剂的抵抗力,免疫逃避和转移.
作为液体活检,TEP显示出前景,但在特异性和方法方面面临挑战.

结论:

TEPs是瘤和宿主之间具有生物学意义的接口.
了解TEP机制对于开发新的癌症诊断和治疗方法至关重要.
克服方法障碍对于将TEP整合到精确癌症管理中至关重要.

关键词:

抗血小板治疗是一种抗血小板疗法.免疫逃逸是一种免疫逃避.液体活检液体活检血小板是血小板的组成部分.瘤微环境是一个微环境.由瘤形成的血小板.

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