结构类似物TOCP和TPHP通过对能量新陈代谢的不同干扰在斑马鱼中诱导免疫毒性
Xinyan Li1, Dongmei Lai2, Yao Yao3
1School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China; Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center, Jieyang 515200, China.
Environmental pollution (Barking, Essex : 1987)
|March 1, 2026
概括
两个阻燃剂,三二甲基酸 (TOCP) 和三酸 (TPHP),对斑马鱼的免疫产生了相反的影响. 它们还通过改变能量代谢来损害抗菌防御.
科学领域:
- 环境毒理学环境毒理学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 甲基有机酸盐阻燃剂 (甲基-OPFRs) 是广泛存在的环境污染物.
- 它们的免疫毒性和水生生物中的机制尚不清楚.
研究的目的:
- 在斑马鱼幼虫中研究TOCP和TPHP的免疫调节作用.
- 阐明它们不同的免疫反应背后的机制.
主要方法:
- 斑马鱼幼虫在天生的免疫期间暴露于TOCP和TPHP.
- 使用了转录和代谢分析.
- 进行了分子对接和动力学模拟.
主要成果:
- TOCP和TPHP诱导了相反的免疫反应 (炎症与抑制).
- 这两种化合物都损害了抗菌能力.
- 观察到能量路径 (糖解,纯素代谢) 的不同调节.
- TPHP显示出与AMPK的快速解离,而TOCP具有持久的结合.
结论:
- 结构类似的TOCP和TPHP在斑马鱼中具有不同的免疫毒性.
- 机制涉及对宿主能量代谢的差异性破坏.
- 对AMPK的结合稳定性可能解释了明显的免疫代谢重编程.
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