在慢性缩性胃炎中,Simo Tang通过PI3K/AKT通路激活来缓解线粒体依赖的亡
Yaqin Hu1, Yue Wan1, Zijing Lu1
1College of Food Science and Engineering, Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Marine Food Engineering Technology Research Center of Hainan Province, Collaborative Innovation Center of Marine Food Deep Processing, Hainan Key Laboratory of Herpetological Research, Sanya 572000, China.
Journal of ethnopharmacology
|March 1, 2026
概括
西莫唐 (SMT) 通过重新激活PI3K/AKT通路,减少炎症和增强抗氧化防御来保护慢性缩性胃炎 (CAG). 这种传统配方可以保持线粒体的功能,并抑制细胞亡,有效地减缓疾病的进展.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
- 胃肠病学 胃肠病学
背景情况:
- 西莫唐 (Simo Tang,简称SMT) 是一种传统的草药配方,几个世纪以来一直用于治疗消化不良和腹部膨胀.
- 它对慢性缩性胃炎 (CAG) 的有效性是公认的,但潜在的药理机制,特别是涉及PI3K/AKT通路,仍然不清楚.
研究的目的:
- 系统地阐明SMT对CAG的治疗机制,使用综合的药理学,in silico和实验方法.
- 为了验证PI3K/AKT途径在SMT的保护作用中的作用.
主要方法:
- 使用UHPLC/MS.识别的SMT的生物活性成分.
- 网络药理学和分子模拟 (对接,MD) 分析了潜在的目标和途径.
- 在体外和体内实验中评估了SMT对胃粘膜损伤,亡,炎症和氧化应激的影响.
主要成果:
- AKT1被确定为SMT对CAG的保护作用的关键调解者.
- SMT恢复了PI3K/AKT通路,调节了与亡相关的蛋白质 (Bcl-2,Bax),并保持了线粒体的完整性.
- SMT降低了促炎性细胞因子 (IL-6,TNF-α),增加了抗氧化活性 (SOD),并降低了氧化应激标志物 (ROS,MDA).
结论:
- SMT通过编排PI3K/AKT级联来减轻CAG的进展.
- 这种配方增强了抗氧化能力,维持了线粒体平衡,并抑制了亲细胞缩和亲炎症信号传递.
- SMT有效地减轻胃粘膜损伤,并延缓CAG的进展.
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