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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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阿斯巴甜食用与癌症风险之间的关联:来自大型前性队列的证据.

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概括

阿斯巴甜的消费与癌症风险增加有关,包括与肥胖有关的和与肥胖无关的癌症. 由于缺乏明确的剂量反应关系,需要进一步研究.

关键词:
人工甜味饮料的人工甜味饮料亚斯巴甜胺是一种癌症 癌症 癌症 癌症 癌症低热量甜味剂 低热量甜味剂肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖预期的队列研究.

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科学领域:

  • 在瘤学瘤学.
  • 营养流行病学 营养流行病学
  • 公共卫生 公共卫生

背景情况:

  • 亚斯巴甜是一种常见的低热量甜味剂,已被归类为可能致癌的.
  • 不一致的流行病学证据需要对阿斯巴甜和癌症风险进行进一步的大型前性研究.
  • 需要特别关注与肥胖有关的癌症和阿斯巴甜的消费.

研究的目的:

  • 调查阿斯巴甜摄入量与所有癌症综合风险之间的关联.
  • 检查与肥胖相关的癌症 (ObCa) 和非肥胖相关的癌症 (非ObCa) 相关的阿斯巴甜摄入量.
  • 分析阿斯巴甜与消化系统和女性生殖系统的ObCa亚组之间的联系.

主要方法:

  • 利用了100004名成年人的癌症预防研究II (CPS-II) 营养队列 (NC) 的数据.
  • 通过1999年和2003年的食物频率调查问卷评估了饮料和包装中的阿斯巴甜的摄入量.
  • 采用多变量调整的考克斯比例危险模型来分析癌症风险,根据基线体重状态进行调整.

主要成果:

  • 与非消费者相比,阿斯巴甜的消费者对所有癌症的风险都更高,包括非ObCa,ObCa,消化ObCa和女性生殖ObCa.
  • 调整后的危险比率表明各种癌症类型的风险增加 (例如,所有癌症的aHR=1.13).
  • 没有观察到明确的剂量反应关系,并没有根据体重状况改变关联.

结论:

  • 阿斯巴甜的消费与癌症风险增加有关,包括与肥胖有关的癌症和与肥胖无关的癌症.
  • 这些发现表明阿斯巴甜与癌症发病率增加之间存在潜在联系.
  • 由于没有剂量反应关系,因此需要谨慎解释和进一步调查.