在CATHIS核心的Inter-Rater可靠性和可用性,用于顺势疗法干预研究
Martin Loef1, Petra Weiermayer2, Katharina Gaertner3
1Institute of Integrative Medicine, University of Witten/Herdecke, Germany; Society for Clinical Research, Berlin, Germany.
对于顺势疗法干预研究 (CATHIS) 核心的批判性评估工具显示出良好的可靠性可信度,但与一致性和临床相关性作斗争. 在它在系统审查中使用之前,需要进行改进.
科学领域:
- 顺势疗法的研究方法学.
- 基于证据的医学评估.
背景情况:
- 顺势疗法干预研究的批判性评估工具 (CATHIS) 核心旨在评估顺势疗法研究.
- 它侧重于可信度,连贯性和临床相关性.
- 该研究旨在评估其评级者之间的可靠性,可行性和面部有效性.
研究的目的:
- 评估CATHIS核心工具的评级者之间的可靠性.
- 评估CATHIS核心的可行性和面对有效性.
- 确定该工具是否适用于对顺势疗法干预措施的系统审查.
主要方法:
- 一项涉及四名独立评审人的横截面研究,将CATHIS核心应用于28项顺势疗法干预试验.
- 使用Fleiss的 κ和Gwet的AC2测量了评价者之间的可靠性.
- 通过评分和共识时间来评估可行性;通过评论员的回复来衡量面部有效性.
主要成果:
- 评价者之间的可靠性在各个领域有显著差异:可信度好 (κ=0.66),但对连贯性 (κ=0.28) 和临床相关性 (κ=0.32) 差不多.
- 平均评级时间为65.8分钟,共识时间为17.7分钟.
- 面部有效性表明适度接受,但应用不一致.
结论:
- 卡西斯核心显示可重复的可信度评级,但对一致性和临床相关性有脆弱的协议.
- 该工具带来了一个不小的评级负担.
- 目前的可靠性不足以进行系统审查,需要有针对性的改进.
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