癌症相关纤维细胞在非小细胞肺癌治疗中:挑战和机遇
Siyou Deng1, Yu Li2, Lin Peng1
1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Biochimica et biophysica acta. Reviews on cancer
|March 1, 2026
概括
在非小细胞肺癌 (NSCLC) 中,与癌症相关的纤维细胞 (CAF) 影响治疗的有效性. 了解CAF异质性对于开发针对NSCLC的成功向疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境研究 研究
背景情况:
- 非小细胞肺癌 (NSCLC) 带来了严重的发病率和死亡率挑战.
- 瘤微环境 (TME),特别是与癌症相关的纤维细胞 (CAF),在NSCLC的进展和治疗耐药性方面发挥着关键作用.
- 目前对NSCLC的治疗策略通常由于TME复杂性而产生有限的益处.
研究的目的:
- 在NSCLC TME中审查CAF的各种子集.
- 阐明CAFs影响各种NSCLC治疗的疗效的机制,包括化疗,放射治疗,免疫治疗和向治疗.
- 综合转化进展,并确定在NSCLC中针对CAF的战略的局限性和未来机会.
主要方法:
- 在NSCLC中对CAF的研究进行了全面的文献综述.
- 对CAF异质性,起源,功能和可塑性的分析.
- 检查CAF与不同治疗方式的相互作用.
- 对CAF向治疗的翻译数据的综合.
主要成果:
- 在NSCLC中,CAF在起源,定义和功能方面表现出显著的异质性.
- CAF的可塑性使有效的向治疗方法的开发变得复杂.
- 一些针对CAF的干预措施表现出矛盾的效果,包括加速疾病进展.
- 在NSCLC中,CAFs对化疗,放射治疗,免疫治疗和向治疗的反应具有关键影响.
结论:
- 在NSCLC中准CAF是一个有前途的治疗途径,但必须解决与异质性和可塑性相关的挑战.
- 更深入地了解特定的CAF子集及其作用对于设计有效和安全的治疗策略至关重要.
- 未来的研究应侧重于克服目前的局限性,以推进针对CAF的治疗方法的临床转化,以改善NSCLC患者的治疗结果.
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