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维生素D缺乏和干眼病:一个回顾性队列研究

Shon B Shmushkevich¹, Sandi Bajrami², Benjamin Beauchamp³

¹Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL.

American journal of ophthalmology

|March 1, 2026

概括

维生素D缺乏与患干眼病 (DED) 的风险更高有关. 这项研究表明,维生素D缺乏可能是DED的可修改风险因素.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

干眼病 (DED) 是一种普遍存在的眼表面疾病,影响视力和生活质量.
维生素D具有抗炎和免疫调节功能,其缺乏与包括眼睛表面疾病在内的各种健康状况有关.

研究的目的:

调查维生素D缺乏和干眼病 (DED) 的发生率之间的联系.

主要方法:

一项回顾性队列研究分析了超过1200万成年人的非识别电子健康记录.
患有维生素D缺乏症 (ICD-10代码E55) 的患者的倾向性得分与对照者匹配1:1.
进行了时间到事件分析,以比较两组之间的DED (ICD-10代码H04.12) 的累积发病率.

主要成果:

维生素D缺乏与显著增加患DED的风险相关 (危险比:1.286,p < 0.001).
风险比为1.242,赔率比为1.250,表明维生素D缺乏群体中DED的发病率更高.
限制包括依赖诊断代码和缺乏血清维生素D水平数据.

结论:

维生素D缺乏与发生干眼病的风险增加有关.
这些发现凸显了维生素D缺乏作为DED的潜在可修改风险因素.
需要进一步的研究,包括前性研究,以探索维生素D补充剂在DED预防和管理中的作用.

关键词:

的 DEDED 的 DED.干眼疾病干眼疾病维生素D 维生素D是一种维生素.

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