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Updated: Mar 3, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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通过通过氨基酸交换调节抗原处理来优化针对性抗原递送的T细胞反应

Ida Laurén1, Alexandros Kostakis2, Martin Lord1

  • 1Department of Pharmacy and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

International journal of biological macromolecules
|March 1, 2026
PubMed
概括

在抗体结合物中修改标签 (pTag) 会影响稳定性和免疫反应. 像pTagK8L这样的较低亲和度标签在体内减少了T细胞扩张,突出了结合稳定性.

关键词:
这些ADC是ADCs.双特异性抗体 双特异性抗体类疫苗 类疫苗有针对性的交付目标.

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