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在模拟目标试验时应考虑的实用要素

Viet-Thi Tran1, Raphaël Porcher1, Elodie Perrodeau2

  • 1Center for Research in Epidemiology and Statistics (CRESS), Université Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, F-75004 Paris, France; Centre d'Epidemiologie clinique, AP-HP, Hôpital Hôtel Dieu, F-75004 Paris, France.

Journal of clinical epidemiology
|March 1, 2026
PubMed
概括

目标试验模拟使用观察数据来模仿随机对照试验 (RCT),使干预措施的因果推断成为可能. 本指南阐明了模拟方法和研究人员的关键规划要素.

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Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...