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在老鼠的诱导性毒性性别差异的探索性研究

Shuheng Wen¹, Toshihiko Aki¹, Akihiro Tojo²

¹Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (ST).

The Journal of toxicological sciences

|March 1, 2026

概括

雌性大鼠的 (Tl) 中毒对的损伤不如雄性大鼠那么严重,尽管最初的功能障碍相似. 这表明Tl诱导的毒性存在性别相关的差异,可能是由于荷尔蒙的影响.

科学领域:

毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學.
环境健康环境健康

背景情况:

在急性损伤中的性二态性表明女性比男性更不容易受到影响.
(Tl) 是一种有毒的重金属,会导致系统性疾病,包括功能衰竭.
在T1诱导的毒性中,与性别相关的差异尚未得到充分理解.

研究的目的:

为了研究TI对雌性老鼠脏的影响.
为了阐明Tl诱导的女性毒性的潜在机制.
为了比较雄性和雌性大鼠之间的T1诱导的毒性.

主要方法:

将TL2SO4 (30 mg/kg) 给雌性大鼠使用.
通过生物化学测定,组织病理学和转录组分析在暴露后的2,5和14天评估毒性.
与以前在雄性大鼠中的发现进行比较.

主要成果:

雌性大鼠在TI暴露后5天内出现严重的功能障碍和外髓沉积物.
病理特征与男性相似,但线粒体氧化应激和沉积在女性中不那么广泛.
初步发现表明Tl诱导的损伤存在性别相关的差异.

结论:

在Tl诱导的毒性中存在性别依赖的差异,可能受到性激素的影响.
不同的氧化应激处理,线粒体反应和传送器活性可能导致这些性别差异.
这些见解可能有助于开发治疗TI中毒的治疗策略.

关键词:

沉积物的沉积物造成脏损伤的人.毒性毒性毒性两性二形态主义是什么?塔是一种.转录组转录组就是一个转录组.

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