一种用于不溶性化合物的体外毒性测试的zwitterionic溶剂
Yusuke Kubota1,2, Ayako Hohsaka2, Eishu Hirata3
1Suntory Holdings Limited.
The Journal of toxicological sciences
|March 1, 2026
概括
OE2imC3C,一种zwifterionic液体,没有表现出基因毒性,肝细胞毒性低于DMSO. 这种溶剂可以防止对像基酸这样的溶解性较差的化合物的毒性测试中出现人工物.
科学领域:
- 绿色化学是一种绿色化学.
- 毒理学 毒理学 毒理学
- 材料科学 是一种材料科学.
背景情况:
- 兹威特离子液体正在成为具有低毒性的溶剂.
- 对于OE2imC3C的安全性数据有限,这阻碍了其在毒性测试中的使用.
- 了解OE2imC3C的安全概况对于其在生物测试中的应用至关重要.
研究的目的:
- 为了全面评估OE2imC3C.C.的安全概况.
- 与DMSO相比,评估其基因毒性和肝细胞毒性.
- 为了确定其适用于难以溶解的化合物的毒性测定.
主要方法:
- 细菌逆变异试验和基因毒性染色体异常试验.
- 肝细胞毒性测定比较OE2imC3C库存溶液 (OS) 和DMSO.
- 在酸毒性测试中OS的应用.
- 汉森溶解度参数用于确认对食品化合物的一般适用性.
主要成果:
- 在细菌逆转基因突变和染色体异常试验中,OE2imC3C没有表现出基因毒性.
- 与DMSO相比,OS的肝细胞毒性较低.
- OS使得对基酸的毒性进行了准确的评估,与DMSO不同,由于未溶解的晶体导致了虚假的毒性.
- 汉森溶解度参数证实了OS适用于各种与食品有关的化合物.
结论:
- OE2imC3C是一种安全的zwitterionic液体,没有遗传毒性或显著的肝细胞毒性问题.
- 在涉及不易溶解化合物的毒性测试中,OS是DMSO的优越溶剂,防止测试工件.
- 在食品和药物研究中,OE2imC3C为准确的毒性评估提供了一个有希望的替代溶剂.
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