PFAS对五种主要的人类癌症的健康影响:关于分子病变发生的网络毒理学观点
Zhen Qi1, Xuefei Yang2, Zhuning Geng1
1School of Environment, Tsinghua University, Beijing 100084, China; State Key Laboratory of Regional Environment and Sustainability, Beijing 100084, China.
Journal of environmental sciences (China)
|March 1, 2026
概括
像PFOA和PFOS这样的和多基基物质 (PFAS) 显示出不同的癌症机制. PFOA利用PPAR通路,而PFOS影响活性氧物种和核糖体,影响人类主要癌症.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 癌症研究 癌症研究
背景情况:
- 越来越多的证据将和多基基物质 (PFAS) 与人类癌症风险联系起来.
- 关于PFASs的特定致癌机制的研究有限.
- 网络毒理学和高通量测序为研究这些机制提供了新的方法.
研究的目的:
- 为了分析 perfluorooctanoic acid (PFOA) 和 perfluorooctane sulfonate (PFOS) 在人类五种主要癌症中的致癌作用和机制.
- 为了确定参与PFAS诱导的致癌的共同和独特的分子途径.
- 为PFASs的健康评估和机制性验证提供基础.
主要方法:
- 网络毒理学分析.
- 高通量测序数据分析.
- 在胃,结肠直肠,肝脏,脏和乳腺癌中对PFOA和PFOS影响的比较分析.
主要成果:
- 在PFOS的致癌过程中涉及24个丰富的通路,在直肠,肝脏和脏癌症中发现了Ribosome通路.
- 在所有五种癌症中,PFOA致癌涉及32个丰富的途径,特别是氧酶增殖器激活受体 (PPAR) 信号途径.
- 酸主要通过PPAR途径起作用,而酸则破坏活性氧物种和核糖体.
结论:
- 尽管PFOA和PFOS结构相似,但它们表现出不同的致癌机制.
- 由PFOA诱导的癌症与PPAR信号传递有关.
- PFOS诱导的癌症与反应性氧物种和核糖体通路的干扰有关.
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