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皮米辛硫化物通过使用斑马鱼胚胎抑制铁亡来改善由硫酸铜引起的炎症

Siyu Chen¹, Junyu Liang¹, Tingting Lin¹

¹State Key Laboratory of Cellular Stress Biology, Department of Endocrinology, Xiang'an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.

Journal of environmental sciences (China)

|March 1, 2026

概括

皮米辛 (PMS) 滴氧化为皮米辛硫化物 (PMS-S) 增强了安全性和抗炎作用. PMS-S通过抑制巨细胞活动和铁化来抑制炎症,提供一种潜在的治疗剂.

科学领域:

药理学和毒理学药理学和毒理学
自然产品化学自然产品化学
炎症研究炎症研究

背景情况:

培米辛 (PMS) 是一种来自Fritillaria的化合物,具有抗炎作用的潜力,但其水溶性差,生物安全性不明.
硫化产生皮米辛硫化物 (PMS-S),提高溶解度,但其安全性和抗炎机制需要研究.

研究的目的:

使用斑马鱼胚胎毒性试验评估PMS和PMS-S的生物安全性.
在斑马鱼的硫酸铜诱导炎症模型中阐明PMS-S的抗炎机制.

主要方法:

对斑马鱼胚胎进行了急性毒性测试,这些胚胎暴露于不同度的PMS和PMS-S.
在转基因斑马鱼 (Tg (mpeg1:EGFP)) 中建立了一个硫酸铜诱导的炎症模型,以评估PMS-S的影响.
分析了巨细胞迁移,活性氧物种 (ROS) 水平和与铁死相关的基因表达 (acsl4b,fthl28).

主要成果:

在100μmol/L时,PMS在斑马鱼胚胎中诱导了显著的毒性,而PMS-S在100μmol/L时没有显示任何不良影响.
在炎症模型中,PMS-S治疗抑制了巨细胞的迁移和聚合.
PMS-S降低了ROS水平和降低了与铁亡相关的基因,表明铁亡抑制.

结论:

化显著提高了皮米辛的生物安全性.
皮米辛硫化物通过抑制巨细胞活动和抑制铁亡,表现出抗炎活性.
由于其改善的安全性和阐明的抗炎机制,PMS-S是治疗开发的有希望的候选者.

关键词:

抗炎药物抗炎药物抗炎药物生物安全生物安全铁性化 (ferroptosis) 是一种皮米辛硫化物 (PMS-S) 是一种斑马鱼是一种斑马鱼.

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