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Updated: Mar 3, 2026

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[与代谢功能障碍相关的脂肪肝病,与代谢功能障碍相关的脂肪性肝病和临床诊断的骨关节炎:前性队列研究]

Z S Liang¹, W H Gao¹, Z R Zhang¹

¹Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

|March 1, 2026

概括

与代谢功能障碍相关的脂肪肝病 (MAFLD) 和脂肪性肝病 (MASLD) 会增加骨关节炎的风险,尤其是膝关节OA. 肥胖和酒精摄入量是这种关联的关键驱动因素.

科学领域:

肝病学肝病学是一种肝病学.
类风湿病学类风湿病学
代谢疾病代谢疾病

背景情况:

与代谢功能障碍相关的脂肪肝病 (MAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 是普遍存在的疾病.
骨关节炎 (OA) 是全球导致残疾的主要原因.
牛脂性肝病与OA发病率之间的关系需要全面调查.

研究的目的:

评估MAFLD和MASLD之间的关联以及患膝盖,部和手部OA的风险.
探索MAFLD亚型和酒精消费对OA风险的影响.

主要方法:

来自英国生物银行的350,273名参与者的前性分析.
使用多变量Cox比例危险回归来评估OA发病率.
结局包括所有原因的OA,膝盖,部,手部OA和多关节炎.

主要成果:

在该队列中,MAFLD (37.6%) 和MASLD (29.2%) 是普遍存在的.
MAFLD与增加的OA总风险 (HR=1.72) 有关.
超重/代谢功能障碍MAFLD亚型增加了OA风险,而瘦子类型没有. MASLD (HR=1.57) 也增加了OA的风险,特别是在较高的酒精摄入量. MAFLD的OA关联甚至在MASLD.中仍然存在.

结论:

MAFLD和MASLD是OA的重要危险因素,对膝盖OA有显著影响.
肥胖和酒精消费是调解脂肪性肝病和OA之间的联系的关键因素.
这些发现凸显了肝病对关节健康的系统性影响.

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