[ perfluoroalkyl 和 polyfluoroalkyl 物质暴露与生殖寿命之间的关联以及身体活动的改变作用]
1Department of Epidemiology and Statistics, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang 050017, China.
概括
暴露于甲基和多甲基物质 (PFAS) 可能会缩短女性的生殖寿命. 然而,定期的体力活动 (PA) 可以减轻这些不良影响,可能是通过影响脂质代谢和炎症反应.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 是持久性环境污染物,具有潜在的内分泌干扰性.
- 生殖寿命是女性生殖健康和衰老的关键指标.
- 了解环境暴露和生活方式因素对生殖健康的相互作用至关重要.
研究的目的:
- 研究特定PFAS (PFOS,PFOA,PFHxS) 和PFAS混合物的血清度与绝经后妇女的生殖寿命之间的关联.
- 评估身体活动 (PA) 是否改变了PFAS暴露和生殖寿命之间的关系.
- 探索潜在的生物机制,包括脂质代谢和炎症反应,这些关联的基础.
主要方法:
- 利用了来自国家健康和营养检查调查 (1999-2018) 的数据,其中包括2037名绝经后妇女.
- 定义的生殖寿命是初潮和更年期之间的时间.
- 采用加权通用线性模型,受限立方线,加权定量积回归和贝叶斯核机回归来分析PFAS暴露,生殖寿命和PA的修饰作用.
主要成果:
- 较高的PFOS,PFOA,PFHxS和整体PFAS混合物的血清度与更短的生殖寿命显著相关.
- 身体活动显示出潜在的缓解作用,特别是在高水平时,尽管一些PFAS的置信区间很宽.
- 毒基因组分析表明,脂质代谢和炎症反应是关键的生物途径.
结论:
- 高度暴露于常见的PFAS可能会对女性的生殖寿命产生负面影响.
- 身体活动可以作为一种保护因素,有可能减轻PFAS暴露的不良影响.
- 脂质代谢和炎症途径被认为是PFAS影响生殖寿命的机制,PA可能会调节这些共同的目标.
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