在EULAST队列中持续存在的负面症状:对功能结果的影响
Luigi Giuliani1, Pasquale Pezzella1, Giulia M Giordano2
1University of Campania "Luigi Vanvitelli", Naples, Italy.
Schizophrenia (Heidelberg, Germany)
|March 1, 2026
概括
精神分裂症的持续负面症状 (PNS) 显著恶化了功能结果,即使在早期的疾病阶段. 确定这些持久症状的预测因素对于开发有针对性的干预措施以改善患者功能至关重要.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 持续的负面症状 (PNS) 与精神分裂症的功能表现不佳有关.
- 了解混杂和不混杂的负面症状的患病率和影响对于早期干预至关重要.
研究的目的:
- 确认未经证实的持久性负面症状 (PNS) 对中断率和心理社会功能的流行程度和临床影响.
- 探索持久负面症状 (E-NS) 的流行情况及其对功能结果的影响.
主要方法:
- 在精神分裂症试验 (EULAST) 中对欧洲长效抗精神病药物队列进行后期分析.
- 在基线,12个月和18个月评估负面症状,抑郁症,帕金森症,中断率和心理社会功能.
主要成果:
- 在基线时,60.6%的患者有中度负面症状,42.8%符合无证据负面症状的标准.
- 一年后,PNS和E-NS的患病率分别为7.9%和15%,前景一致性为~32%.
- 与非持久性负面症状 (N-PNS) 组相比,12个月和18个月后,PNS和E-NS组的功能显著恶化.
结论:
- 长期持续的负面症状,无论是初级还是二级,显著导致精神分裂症的功能性结果差.
- 需要进一步的研究来确定症状持续的预测因子,以制定有针对性的干预措施.
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