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相关概念视频

Phase Contrast and Differential Interference Contrast Microscopy01:26

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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相关实验视频

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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
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在近红外II窗口中的in vivo微内镜.

Zhisheng Wu1,2, Danyang Xu1, Zideng Dai1

  • 1Department of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.

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概括

一种新的近红外II (NIR-II) 微内镜允许在活哺乳动物的粘膜之外进行深肠成像. 这种非侵入性技术可视化直肠血管和淋巴结,有助于早期发现大肠炎.

关键词:
在生物体内成像成像.大肠炎是一种大肠炎.淋巴结的淋巴结是指淋巴结的微内镜检查是微内镜检查的一种.接近红外II成像技术

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科学领域:

  • 生物医学工程 生物医学工程
  • 光学成像技术的成像
  • 胃肠病学 胃肠病学

背景情况:

  • 深层组织光内镜受到光散射的限制,阻碍了超越粘膜的可视化.
  • 在活哺乳动物中高时空分辨率的跨肠道成像仍然是一个重大挑战.
  • 目前的方法通常需要侵入性手术,限制了纵向研究.

研究的目的:

  • 开发一种非侵入性微内镜,用于超越粘膜的深肠成像.
  • 为了实现高分辨率,直肠血管和淋巴系统的实时可视化.
  • 为了能够及早检测肠道疾病,如大肠炎.

主要方法:

  • 开发一种近红外II (NIR-II) 微内镜系统,其成像波长扩展到1700nm.
  • 使用10μm以下的分辨率在没有手术的情况下对活哺乳动物进行穿直肠成像.
  • 采用广的视野,对直肠结构和腰部淋巴结进行全面的成像.

主要成果:

  • 成功的深肠成像超越粘膜和直肠外成像在10μm以下的分辨率.
  • 实时可视化小鼠直肠不同层的血管网络.
  • 首次对整个腰部淋巴结进行非侵入性成像,揭示了瘤携带小鼠的异常淋巴排水.
  • 在健康小鼠和大肠炎携带的小鼠的直肠血管和腰部淋巴结中观察到明显的光模式,使得早期的病变检测成为可能.

结论:

  • 开发的NIR-II微内镜克服了用于深肠成像的光散射限制.
  • 这项技术提供了前所未有的直肠微血管和淋巴系统的非侵入性可视化.
  • 它为研究肠道微环境-淋巴相互作用和早期疾病诊断提供了新的可能性.