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素抑制严重急性呼吸系统综合征冠状病毒2复制 in vitro

Yethindra Vityala¹, Tugolbai Tagaev², Elmira Mainazarova³

¹Department of Pathology, International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan.

Indian journal of pharmacology

|March 2, 2026

概括

这项研究表明,素显著抑制严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 在人类鼻腔细胞中的复制. 这为fluoxetine作为SARS-CoV-2感染的潜在治疗方法提供了早期证据.

科学领域:

病毒学病毒学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

目前没有有效的抗病毒药物用于严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 细胞进入或复制.
迫切需要针对SARS-CoV-2的新型治疗策略,需要探索现有的药物化合物.

研究的目的:

为了评估体内fluoxetine在抑制SARS-CoV-2复制的疗效.
评估素异构体对人类鼻上皮细胞中的病毒复制的影响.

主要方法:

对两种fluoxetine异构体进行了细胞毒性测试.
素对临床SARS-CoV-2分离物 (菌株IHUMI3) 复制的作用在人类鼻上皮细胞中进行了评估.
测量病毒标位和蛋白质表达以确定抗病毒活性.

主要成果:

素异构体在0.9微克/毫升时显著抑制了SARS-CoV-2,其半最大有效度 (EC50) 为0.39微克/毫升.
任何一种fluoxetine异构体的10μM度都将SARS-CoV-2标位降低了63.9%.
西治疗导致病毒蛋白表达的降低.

结论:

素有效地抑制了SARS-CoV-2在体外的复制.
这些发现表明,素是治疗SARS-CoV-2感染的潜在治疗剂.
进一步的研究是有必要的,以探索fluoxetine对SARS-CoV-2的临床应用.

关键词:

在 COVID-19 疫情中,克塞提因 (fluoxetine) 是一种含有素的药物.选择性血清素再吸收抑制剂选择性血清素再吸收抑制剂严重急性呼吸系统综合征新冠病毒2

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