酸盐纳米颗粒中杀菌剂赫萨可纳的pH响应控制释放
Mohamad Iqhwan Syafiq Baharuddin1, Farhatun Najat Maluin1, Nurin Ilyana Kamis1
1School of Chemical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
ChemPlusChem
|March 2, 2026
概括
奇托 - 赫萨可纳纳米颗粒 (CHEN) 为杀菌剂提供了一个可扩展的,对pH值有反应的输送系统. 这种可持续的方法解决了对传统化学杀菌剂的担忧,显示了受控释放的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 农业化学 农业化学
背景情况:
- 像六可纳这样的化学杀菌剂面临着一些挑战,包括溶解性差,环境持久性以及目标生物体中耐药性的发展.
- 更安全,更有效的传输系统对于可持续农业和有效的害虫管理至关重要.
- 基于纳米载体的系统为提高杀菌剂效率和减少环境影响提供了一个有希望的替代方案.
研究的目的:
- 开发和表征素-六可纳纳米颗粒 (CHEN) 作为基于纳米载体的真菌杀菌剂输送系统.
- 评估CHEN的可扩展性,可重复性和受控释放性质.
- 评估开发的纳米颗粒的pH响应释放动力学和体稳定性.
主要方法:
- 改进的离子凝方法用于纳米粒子合成,优化十倍的生产规模没有离心.
- 使用动态光散射 (DLS),里埃变换红外光谱 (FTIR),热重力测量分析 (TGA),X射线光 (XRF) 和布鲁纳尔-埃梅特-泰勒 (BET) 分析进行了表征.
- 在不同pH值 (4,7和9) 进行的体外释放研究,使用Korsmeyer-Peppas和伪二阶模型进行分析.
主要成果:
- 对于CHEN,其颗粒大小为28.2 nm,实现了高产率 (83.10%) 和负载含量 (15.44%).
- BET分析表明,中孔结构 (26.01 m2/g表面积,30.91 nm孔径) 有助于控制释放.
- 观察到双相,pH响应释放,与pH 7 (45.98%) 相比,pH 4 (70.20%) 和pH 9 (73.10%) 的累积释放更高,符合伪二阶模型.
- 科尔斯迈耶-佩帕斯建模表明,在pH 7时有Fickian扩散,在pH 4和pH 9时有非Fickian传输.
- 体稳定性保持长达6个月.
结论:
- 奇托 - 六可纳纳米颗粒 (CHEN) 是一种可扩展和可重复的纳米载体系统,用于杀剂的输送.
- 这些纳米颗粒具有显著的pH反应和持续释放特征,具有控制释放应用的潜力.
- 切恩为传统化学杀菌剂提供了一个有希望的可持续替代品,解决了关键的环境和有效性问题.
相关概念视频
Modified-Release Drug Delivery Systems: Stimuli-Activated
55
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
55
Modified-Release Drug Delivery Systems: Rate-Programmed I
58
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
58
Site-Targeted Drug Delivery Systems: Polymeric Carriers
63
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
63


