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Updated: Mar 3, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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通过SuFEx辅助方法机械平面化分子

Shengtong Niu1, Yingying Jiang1, Darian W Lewis1

  • 1Department of Chemistry, University of Wyoming, Laramie, Wyoming, USA.

Angewandte Chemie (International ed. in English)
|March 2, 2026
PubMed
概括

这项研究引入了一种无金属的SuFEx点击反应,用于在格拉姆尺度上合成机械平面性 (MPC) 轮素. 然后可以高效地生产Enantiopure MPC罗塔克桑和卡特南,克服了以前的合成挑战.

关键词:
SuFEx SuFEx 是一个卡特纳纳纳斯 (catenane) 是一种机械化性 机械化性机械上相互锁定的分子.罗塔克桑和罗塔克桑的作用

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