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富含巨细胞的处在胆囊癌进展过程中调节肝脏侵袭边缘的T细胞动态

Maolan Li^1,2,3, Zhaonan Liu¹, Shenbing Shan⁴

¹Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The Journal of clinical investigation

|March 2, 2026

概括

胆囊癌肝脏侵袭涉及CXCL9+巨丰富的免疫细胞. 这些位影响CD8+T细胞活性和患者的预后,为免疫疗法提供了潜在的可能性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

肝脏侵袭是胆囊癌 (GBC) 进展中的常见事件.
瘤-肝脏界面微环境在GBC肝脏入侵中的作用尚不清楚.

研究的目的:

在GBC肝脏入侵期间调查瘤肝脏微环境的细胞和分子机制.
在侵袭性边界确定关键细胞组件和基因表达模式.

主要方法:

单细胞和空间转录组学被用来分析瘤-肝脏接口.
一项队列研究评估了已识别的标志物的预后和预测价值.

主要成果:

在瘤肝脏侵袭边缘确定了富含巨细胞的CXCL9+免疫细胞.
两个子类,CXCL9+TRAC+ (CT) 和CXCL9+C1QB+ (CC) 利基,被描述.
通过CXCL9-CXCR3相互作用的CD8+T细胞招募发生在CT小区,而瘤细胞通过CC小区的LGALS4诱导CD8+T细胞耗尽.
高CXCL9和低LGALS4表达与GBC患者的良好预后和更好的抗PD-1免疫治疗反应相关.

结论:

阐明了GBC肝脏入侵的新型细胞和分子机制.
肝脏侵袭边缘中的CXCL9和LGALS4水平对于预测患者的结果和免疫治疗反应具有临床价值.

关键词:

生物信息学是一种生物信息学.癌症免疫疗法癌症免疫疗法免疫学免疫学免疫学在瘤学瘤学.

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