专家意见关于多发性硬化症患者与年龄相关的性激素变化和阴性腺缺陷症:德尔菲共识计划
Riley Bove1, Manuela Simoni2, Camil Castelo-Branco3
1University of California San Francisco Weill Institute for Neurosciences, University of California.
Neurology. Clinical practice
|March 2, 2026
概括
由于多发性硬化症 (MS) 患者的寿命更长,专家建议现在针对MS患者的与年龄相关的荷尔蒙变化和阴激素变化. 这些指南填补了更年期妇女和患有晚期性阴道腺瘤 (LOH) 的男性护理的关键缺口.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 多发性硬化症 (PwMS) 患者的预期寿命增加凸显了需要解决与年龄相关的性激素变化和性腺缩的需要.
- 当前的文献和指导方针不充分地解决了PwMS中的这些具体挑战.
研究的目的:
- 制定实用,专家主导的建议,用于管理与年龄相关的性激素变化和PwMS中的阴性腺体缺陷.
- 解决在MS人口中对这些疾病的理解和管理中发现的差距.
主要方法:
- 一个由15名国际专家组成的多学科指导委员会在6个主题中确定了18个关键临床问题.
- 系统的文献审查为制定建议提供了信息.
- 投票采用了经过修改的Delphi共识方法,涉及23名医疗保健专业人员和1名患者代表.
主要成果:
- 所有18个临床建议都达到了共识 (≥75%的同意).
- 建议涵盖MS女性的高潮症状,更年期对MS的影响,MS男性的LOH和以患者为中心的护理.
- 关键发现包括多发性硬化和高潮症状的潜在重叠,查的需要,更年期妇女MS药物疗效的数据差距,以及激素变化与疾病进展的相互作用.
结论:
- 协商一致的建议提供了一个有价值的框架,以改善与年龄相关的荷尔蒙变化和阴性腺的PwMS患者的护理.
- 强调有必要解决对这种不断增长的患者群体的知识和管理策略的现有差距.
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