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针对细胞源特定的CXCL9信号,用于口腔状细胞癌的免疫治疗

Miao Qiu¹, Ling Wang², Honglin Tang³

¹Department of Pharmacy, Shenzhen Stomatology Hospital (Pingshan) of Southern Medical University, Shenzhen, China.

Frontiers in immunology

|March 2, 2026

概括

在口腔状细胞癌 (OSCC) 中,C-X-C动机化学因子接体9 (CXCL9) 的作用是复杂的,根据其来源,它既具有抗瘤作用,也具有前瘤作用. 针对细胞特异性CXCL9信号传递是克服OSCC免疫疗法耐药性的关键.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

口腔状细胞癌 (OSCC) 带来了重大临床挑战,包括高复发率和对免疫疗法的耐药性.
瘤微环境 (TME) 在OSCC进展和治疗反应中发挥着关键作用.
在TME中,C-X-C动机化学因子接体9 (CXCL9) 表现出矛盾的功能,影响抗瘤免疫力和瘤促进.

研究的目的:

审查CXCL9在OSCC瘤微环境中的多方面的作用.
阐明细胞起源和微环境环境如何决定CXCL9的功能.
通过针对细胞特异性CXCL9信号,提出克服OSCC中免疫检查点阻塞 (ICB) 抵抗的策略.

主要方法:

在OSCC中对CXCL9进行现有研究的文献综述和综合.
分析CXCL9源,微环境和受体表达细胞之间的相互作用.
描述CXCL9影响T细胞反应,调节性T细胞和PD-L1表达的机制.

主要成果:

CXCL9的功能取决于上下文,而不是内在的.
骨髓系衍生CXCL9通常通过招募细胞毒性淋巴细胞来促进抗瘤免疫力.
流体细胞衍生的CXCL9,特别是来自癌症相关纤维细胞的CXCL9,经常促进转移和免疫逃避.

结论:

简单增强或阻断CXCL9不足以治疗OSCC.
要克服ICB耐药性,需要一种针对细胞特异性CXCL9信号的精密医学方法.
了解和治疗性操纵源特异性CXCL9网络对于改善OSCC结果至关重要.

关键词:

在CXCL9中使用.纤维细胞细胞是什么?免疫检查点封锁封锁口腔状细胞癌的癌症.瘤微环境是一个微环境.

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