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重新编程免疫抑制性乳腺癌微环境:整合细胞,代谢和结构点,以合理的免疫疗法

Chang Ma^1,2, Hoon Koon Teoh², Yang Zhao³

¹School of Public Health, Jilin Medical University, Jilin, Jilin, China.

Frontiers in immunology

|March 2, 2026

概括

这篇评论探讨了乳腺癌瘤免疫微环境 (TIME) 和免疫抑制. 它强调了将"冷"瘤转化为"热"的策略,以改善免疫疗法和克服耐药性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

乳腺癌的异质性和死亡率受到瘤免疫微环境 (TIME) 的影响.
时间内的免疫抑制阻碍了有效的癌症治疗.
了解时间的复杂性对于开发更好的乳腺癌疗法至关重要.

研究的目的:

审查了解乳腺癌的最新进展时间复杂性.
突出免疫抑制机制阻碍治疗疗效.
讨论克服耐药性的新型免疫治疗策略.

主要方法:

关于乳腺癌的最新研究的整合 TIME.
对当前和新兴免疫治疗方法的批判性评估.
讨论新的策略,如代谢调节和 stromal 重编程.

主要成果:

鉴定乳腺癌中免疫抑制机制.
探索将免疫学上"冷"的瘤转化为"热"的表型的策略.
突出新兴的生物标志物策略,包括空间转录和液体活检.

结论:

有效的免疫疗法需要克服TIME介导的免疫抑制.
精密组合疗法和代谢调节显示出对抗性的承诺.
生物标志物策略对于免疫疗法方案的实时适应至关重要.

关键词:

乳腺癌乳腺癌乳腺癌免疫逃避免疫逃避免疫疗法免疫疗法巨细胞的可塑性巨细胞的可塑性代谢重编程是指代谢重编程.瘤微环境是一个微环境.

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