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多基因生长得分和妊娠年龄出生体重较大的风险

Maha Aamir¹, Maisa Feghali², Lynn Yee³

¹Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27607, USA.

Journal of the Endocrine Society

|March 2, 2026

概括

多基因生长分数 (PGS) 可以帮助识别胎儿在妊娠年龄 (LGA) 出生体重较大时面临更高风险. 这种遗传风险评估对于身体质量指数 (BMI) 高的母亲尤其有用.

科学领域:

生殖生物学生殖生物学
遗传学遗传学是一个
产周医学产周医学

背景情况:

对于妊娠年龄 (LGA) 的出生体重很大,对后代构成显著的短期和长期健康风险.
胎儿遗传学是LGA出生体重的一个潜在贡献因素.
识别有风险的胎儿对于及时干预和改善新生儿结果至关重要.

研究的目的:

评估多基因生长得分 (PGS) 和LGA出生体重之间的关联.
评估PGS,孕产妇体重指数 (BMI) 和孕产妇血糖在预测LGA出生体重风险方面的相互作用.
确定PGS在识别LGA出生体重风险增加的胎儿中的实用性.

主要方法:

之前开发的LGA出生体重的PGS是使用3286名无双双的个体的后代DNA计算的.
统计分析包括单向ANOVA,奇二次测试和规则化的线性模型.
这项研究检查了PGS第三种动物,母亲的BMI和葡萄糖挑战测试结果与LGA出生体重风险之间的关系.

主要成果:

第一个三分之一的PGS与LGA出生体重的风险降低有关 (aOR 0.71,95% CI 0.53-0.94).
相反,第三个PGS三位数与LGA出生体重的风险增加有关 (aOR1.29,95%CI1.02-1.63).
在母亲BMI≥35kg/m2和第二或第三个PGS tertile的个体中观察到LGA出生体重的最高几率.

结论:

多基因生长分数 (PGS) 显示出有潜力识别妊娠年龄 (LGA) 出生体重较大风险的胎儿.
孕产妇肥胖症的预测价值在孕妇肥胖症 (BMI ≥35 kg/m2) 导致的妊娠并发症中尤为明显.
将遗传风险评分整合到产前护理中,可能会改善对LGA出生体重有风险的怀孕的管理.

关键词:

孕期糖尿病孕期糖尿病对于妊娠年龄来说很大,出生时的体重很大.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖多基因分数的多基因分数.怀孕怀孕怀孕怀孕怀孕

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