2型糖尿病的年轻成年人中MASLD查率低:一项回顾性队列研究
Chloe A de Crecy1, Qiang Yang2, Mei Liu2
1Division of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Journal of the Endocrine Society
|March 2, 2026
概括
在患有2型糖尿病 (T2D) 的年轻人中,经常错过对代谢功能障碍相关的脂肪性肝病 (MASLD) 的查. 早期发现有风险的MASLD对于预防严重的肝脏并发症至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响70%的2型糖尿病 (T2D) 的成年人,增加MASH,纤维化和肝硬化风险.
- 目前的研究往往忽视了MASLD在T2D年轻成人群体中的流行率和查.
研究的目的:
- 评估在接受门诊护理的被诊断为T2D的年轻成年人中MASLD查的频率.
- 突出需要在这个人口群体中改进MASLD的查协议.
主要方法:
- 一项回顾性队列研究分析了2018年至2022年期间在第三级护理中心治疗T2D的年轻成年人 (18-44岁) 的数据.
- 风险代谢功能障碍相关的脂肪肝炎 (MASH) 通过振动控制的短暂弹性图谱,MRE或肝脏活检来诊断.
主要成果:
- 在6891名参与者中,16%的人患有MASLD,与没有MASLD的人相比,心脏代谢风险因素和心血管疾病的发病率更高.
- 只有12%的MASLD患者接受了进一步调查,失脂症,ALT升高或多种糖尿病药物是显著的相关因素.
- 在接受调查的人群中,38%的人有MASH风险,FIB-4指数在16%的MASLD患者中升高.
结论:
- 在患有T2D的年轻成年人中,对MASLD的查往往是不充分的.
- 需要提高认识和准确的非侵入性工具来查2型糖尿病的年轻人中风险MASH,以防止疾病的进展.
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