在精准医学时代,利切除术的作用
Giacomo Garone1, Alice Innocenti1, Alessandro De Benedictis2
1Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Frontiers in neurology
|March 2, 2026
概括
射频息切除术 (RP) 提供了一种可行的救援疗法,用于儿童严重的医疗耐药性 dystonia. 虽然短期的改善很常见,但长期的好处会减少,复发率很高,特别是在脑中.
科学领域:
- 神经外科 神经外科
- 儿科神经学 儿科神经学
- 运动障碍 运动障碍
背景情况:
- 随着深度大脑刺激 (DBS) 的出现,射频息术 (RP) 的使用量有所减少.
- 对于无法接受DBS的儿科 dystonia患者来说,RP仍然是一个可行的选择.
- 有限的证据表明RP在儿科 dystonia 的长期疗效.
研究的目的:
- 评估RP的安全性,可行性和长期结果在患有医疗耐药性 dystonia 的儿童中.
- 评估RP在管理状态 (SD) 和其复发方面的有效性.
- 确定RP作为救援疗法的作用,当DBS是禁忌.
主要方法:
- 对18名儿科患者进行了21次RP手术的回顾性分析.
- 结果使用临床全球印象改善量表进行评估.
- SD复发是病史中患有状态 dystonicus 的患者的关键结果衡量标准.
主要成果:
- 16名患者中有12名患者在RP后3个月有所改善;长期改善下降.
- 六名患有持续状况低性病 (SD) 的患者表现出症状减轻.
- 观察到显著的SD复发 (8/18名患者),特别是在脑患者中.
结论:
- RP是一种可行的救援疗法,用于严重的医疗耐药性 dystonia,提供短期的好处.
- 长期疗效有限,SD复发率高,特别是在动力障碍性脑中.
- 当DBS是禁忌或不合适时,RP是儿科 dystonia 的一个有价值的考虑因素.
相关概念视频
01:30Psychosurgery
2.1K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
2.1K
01:29Pharmacogenomics: Identification of New Drug Targets
53
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
53
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K